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Moving out: mobilizing activated T cells from lymphoid tissues



The intensity of cytokine-induced signaling by the kinase PI(3)K subunit p110? proves to be an important regulator of T cell migration patterns. High PI(3)K activity functions through the nutrient and bioenergetic sensor mTOR to modulate the transcription factor KLF2 and thereby the repertoire of tissue-homing receptors expressed on effector T cells.


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