Articles and News for Jul08
  1. ATP-sensitive potassium channels mediate survival during infection in mammals and insects

  2. A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15

  3. A common genetic risk factor for colorectal and prostate cancer

  4. A common variant of HMGA2 is associated with adult and childhood height in the general population

  5. A cultural historian's history of biology

  6. A gene harvest revealing the archeology and complexity of human disease

  7. A gene in the multidrug and toxic compound extrusion (MATE) family confers aluminum tolerance in sorghum

  8. A genetic view of Jewish history

  9. A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease

  10. A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21

  11. A genome-wide association study of global gene expression

  12. A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk

  13. A haplotype map for the laboratory mouse

  14. A high-resolution atlas of nucleosome occupancy in yeast

  15. A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia

  16. A navigator for human genome epidemiology

  17. A new identity for the elusive intestinal stem cell

  18. A nonsynonymous functional variant in integrin-?M (encoded by ITGAM) is associated with systemic lupus erythematosus

  19. A promoter polymorphism in the CASP8 gene is not associated with cancer risk

  20. A single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegans

  21. A single positively selected West Nile viral mutation confers increased virogenesis in American crows

  22. A step forward for restless legs syndrome

  23. A textbook for all seasons

  24. A timely guide to the genome

  25. A treasure trove for lipoprotein biology

  26. Adaptive drool in the gene pool

  27. Adding pathogens by genomic subtraction

  28. Aging and cancer: killing two birds with one worm

  29. All in the mind

  30. America competes?for now

  31. An Arabidopsis haplotype map takes root

  32. An ENU-induced mutant archive for gene targeting in rats

  33. Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations

  34. Ancestral reconstruction of segmental duplications reveals punctuated cores of human genome evolution

  35. Anne McLaren 1927?2007

  36. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

  37. Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes

  38. Axons need glial peroxisomes

  39. BRCA1?sowing the seeds crooked in the furrow

  40. Basal bodies, kinocilia and planar cell polarity

  41. Bayesian inference of epistatic interactions in case-control studies

  42. Bi-orientation of achiasmatic chromosomes in meiosis I oocytes contributes to aneuploidy in mice

  43. Blood-strong love

  44. Bringing age-related macular degeneration into focus

  45. Building in resistance to endothelial cell death

  46. Cancer drugs to treat birth defects

  47. Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis

  48. Ciliary proteins link basal body polarization to planar cell polarity regulation

  49. Coevolution in the tumor microenvironment

  50. Common and rare variants in multifactorial susceptibility to common diseases

  51. Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk

  52. Common genetic variation near MC4R is associated with waist circumference and insulin resistance

  53. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer

  54. Common variants in WFS1 confer risk of type 2 diabetes

  55. Common variants on chromosome 5p12 confer susceptibility to estrogen receptor?positive breast cancer

  56. Compete, collaborate, compel

  57. Conflicting evidence on the frequency of ESR1 amplification in breast cancer

  58. Copy-number analysis goes more than skin deep

  59. Corrigendum: Genome-wide analysis of mammalian promoter architecture and evolution

  60. Corrigendum: Mapping autism risk loci using genetic linkage and chromosomal rearrangements

  61. Corrigendum: Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning

  62. Corrigendum: Spontaneous DNA breakage in single living Escherichia coli cells

  63. Corrigendum: Variation in FTO contributes to childhood obesity and severe adult obesity

  64. C-terminal truncations in human 3?-5? DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy

  65. Cystatin C inhibits amyloid-? deposition in Alzheimer's disease mouse models

  66. Cystatin C modulates cerebral ?-amyloidosis

  67. DNA and aging

  68. DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice

  69. Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

  70. Delivery codes for fly transgenics

  71. Desegregating science and the public

  72. Developing genetics for developing countries

  73. Diet and the evolution of human amylase gene copy number variation

  74. Discovery of a previously unrecognized microdeletion syndrome of 16p11.2?p12.2

  75. Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes

  76. Disentangling the roots of inherited hair disorders

  77. Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response

  78. Division of labor among meiotic genes

  79. Double Dutch for duplications

  80. Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs

  81. Dynamic evolution of the innate immune system in Drosophila

  82. ESR1 gene amplification in breast cancer: a common phenomenon?

  83. Efficient mapping of mendelian traits in dogs through genome-wide association

  84. Epigenetic regulation and the variability of gene expression

  85. Erasure of MLH1 methylation in spermatozoa?implications for epigenetic inheritance

  86. Evolution of chromosome organization driven by selection for reduced gene expression noise

  87. Evolutionary plasticity of genetic interaction networks

  88. Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids

  89. From X-rays to aging

  90. From gene expression to disease risk

  91. Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy

  92. Genetic basis of proteome variation in yeast

  93. Genetic determinants of hair, eye and skin pigmentation in Europeans

  94. Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

  95. Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis

  96. Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice

  97. Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24

  98. Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions

  99. Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides

  100. Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors

  101. Genomic rearrangements in the spotlight

  102. Germline gain-of-function mutations in RAF1 cause Noonan syndrome

  103. Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1?like phenotype

  104. Global diversity and evidence for coevolution of KIR and HLA

  105. HDAC2 deficiency and histone acetylation

  106. HIV-1 positive feedback and lytic fate

  107. Hairs and heirs

  108. High-maintenance proteins and hypertriglyceridemia

  109. How microRNAs choose their targets

  110. How the dog got its spots

  111. Human Variome Microattribution Reviews

  112. Hypoxic reprogramming

  113. IL-7R? and multiple sclerosis risk

  114. ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms

  115. Impaired glycosylation and cutis laxa caused by mutations in the vesicular H+-ATPase subunit ATP6V0A2

  116. Interleukin 7 receptor ? chain (IL7R) shows allelic and functional association with multiple sclerosis

  117. Islamic ethical framework for research into and prevention of genetic diseases

  118. Islamic principles and decision making in bioethics

  119. John Hilton Edwards 1928?2007

  120. Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes

  121. Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans

  122. Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis

  123. Lung stem cells in the balance

  124. Marcy Carlson Speer 1959?2007

  125. Measurement of the human allele frequency spectrum demonstrates greater genetic drift in East Asians than in Europeans

  126. MicroRNAs in facial development

  127. Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family?mediated transcriptional activation of TGF?2

  128. Molecular screening for new fusion genes in cancer

  129. Multiple ADH genes are associated with upper aerodigestive cancers

  130. Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia

  131. Mutations in LRP2, which encodes the multiligand receptor megalin, cause Donnai-Barrow and facio-oculo-acoustico-renal syndromes

  132. Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth

  133. Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

  134. Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11

  135. Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation

  136. Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy

  137. Mutations in mRNA export mediator GLE1 result in a fetal motoneuron disease

  138. Mutations in smooth muscle ?-actin (ACTA2) lead to thoracic aortic aneurysms and dissections

  139. Mutations in the cyclin family member FAM58A cause an X-linked dominant disorder characterized by syndactyly, telecanthus and anogenital and renal malformations

  140. Mutations in the gene encoding the 3?-5? DNA exonuclease TREX1 are associated with systemic lupus erythematosus

  141. Network modeling links breast cancer susceptibility and centrosome dysfunction

  142. New models of collaboration in genome-wide association studies: the Genetic Association Information Network

  143. New susceptibility genes for ulcerative colitis

  144. Newly identified genetic risk variants for celiac disease related to the immune response

  145. Newly identified loci that influence lipid concentrations and risk of coronary artery disease

  146. On the subspecific origin of the laboratory mouse

  147. Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL

  148. PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos

  149. PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis

  150. Patchwork women

  151. Pinpointing expression differences

  152. Plant breeders go back to nature

  153. Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus

  154. Population genomics of human gene expression

  155. Positively disruptive

  156. Prader-Willi and snoRNAs

  157. Principal component analysis of genetic data

  158. Progress and prospects in rat genetics: a community view

  159. Promoter regions of many neural- and nutrition-related genes have experienced positive selection during human evolution

  160. Psoriasis is associated with increased ?-defensin genomic copy number

  161. RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis

  162. RNA toxicity in myotonic muscular dystrophy induces NKX2-5 expression

  163. Recombination and linkage disequilibrium in Arabidopsis thaliana

  164. Red sky in the morning, shepherd's warning

  165. Re-examining the role of cytochrome c in cell death

  166. Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis

  167. Reply to ?A promoter polymorphism in the CASP8 gene is not associated with cancer risk?

  168. Reply to ?Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations?

  169. Reply to ?ESR1 gene amplification in breast cancer: a common phenomenon??

  170. Reply to ?HDAC2 deficiency and histone acetylation?

  171. Rescuing distal crossovers

  172. Research Highlights

  173. Research highlights

  174. Rheumatoid arthritis association at 6q23

  175. Rhythm is not enough

  176. Risk loci, biological candidates and biomarkers

  177. Risky business

  178. Salt wasting and blood pressure

  179. Seymour Benzer 1921?2007

  180. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

  181. Sizing up human height variation

  182. Splinkerette PCR for more efficient characterization of gene trap events

  183. Stalled polymerases and transcriptional regulation

  184. Starting well in Europe

  185. Sudden and unexpected

  186. TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

  187. THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia

  188. Target mimicry provides a new mechanism for regulation of microRNA activity

  189. Target mimics modulate miRNAs

  190. The NCBI dbGaP database of genotypes and phenotypes

  191. The beginning of the ends

  192. The developing mosaic of autoimmune disease risk

  193. The emerging landscape of breast cancer susceptibility

  194. The hippocratic finger points the blame at PGE2

  195. The imprinted gene Magel2 regulates normal circadian output

  196. The not-so-silent X

  197. The role of site accessibility in microRNA target recognition

  198. The spindle checkpoint rescues the meiotic segregation of chromosomes whose crossovers are far from the centromere

  199. Thromboxane synthase mutations in an increased bone density disorder (Ghosal syndrome)

  200. Touching Base

  201. Touching base

  202. Trial and error

  203. Two independent alleles at 6q23 associated with risk of rheumatoid arthritis

  204. Two sides of the same coin

  205. Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes

  206. Two ways to make an mtDNA bottleneck

  207. Ultraconservation identifies a small subset of extremely constrained developmental enhancers

  208. Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans

  209. Variation in complement factor 3 is associated with risk of age-related macular degeneration

  210. Variation in interleukin 7 receptor ? chain (IL7R) influences risk of multiple sclerosis

  211. What causes mitochondrial DNA deletions in human cells?

  212. What everybody should know about the rat genome and its online resources

  213. Widespread microRNA repression by Myc contributes to tumorigenesis

  214. Year of the Rat

    215. Find this article in Google