TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
Recently, TDP-43 was identified as a key component of ubiquitinated aggregates in amyotrophic lateral sclerosis (ALS), an adult-onset neurological disorder that leads to the degeneration of motor neurons. Here we report eight missense mutations in nine individuals?six from individuals with sporadic ALS (SALS) and three from those with familial ALS (FALS)?and a concurring increase of a smaller TDP-43 product. These findings further corroborate that TDP-43 is involved in ALS pathogenesis.
Barack Obama said his plan to end the Iraq war was unchanged and he was puzzled by the sharp reaction to his statement that he might "refine" his timetable for withdrawing U.S. combat troops.
AFP - The United States military wanted to test deadly nerve gases on Australian troops in a remote area of far north Queensland in the 1960s but Canberra refused, a report said Sunday.
