Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)
Iron deficiency is usually attributed to chronic blood loss or inadequate dietary intake. Here, we show that iron deficiency anemia refractory to oral iron therapy can be caused by germline mutations in TMPRSS6, which encodes a type II transmembrane serine protease produced by the liver that regulates the expression of the systemic iron regulatory hormone hepcidin. These findings demonstrate that TMPRSS6 is essential for normal systemic iron homeostasis in humans.
Democrat Barack Obama's appeal to  centrist voters has further opened the door to Republican claims his message of change only applies to the positions he has taken in the past.
AP - Iran indicated Saturday that it has no plans to meet a key Western demand that it stop enriching uranium, a day after Tehran sent the European Union a response to an international offer of incentives for halting enrichment.
AP - The call girl involved in a scandal that brought down New York's former governor has dropped a lawsuit claiming "Girls Gone Wild" founder Joe Francis exploited her image and name on the Internet.
