Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis
We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 × 10?8 in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18?1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies.
The historic takeover of Fannie Mae and Freddie Mac, which could come as soon as this weekend, moved to the forefront of the presidential campaign Saturday.
In the arena that night, the whole last minute was drowned out by cheers — and then when the soaring music swelled, the confetti rained down as the harbinger of balloons and the hopeful first family took the stage, forget about it — it was a perfect end to a convention that last Monday, no one even knew if it would happen. But it did, and I'm so glad to have been there.
