Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease. These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases.
In a sharp turnaround, the Republican candidates has opened a 5-point lead on his Democratic rival and is seen as a stronger manager of the economy, according to a Reuters/Zogby poll.
AFP - Georgia's South Ossetia and Abkhazia regions planned rallies Thursday to ask Russia for recognition as independent states, two weeks after Russian troops occupied both provinces.
