A nonsynonymous functional variant in integrin-?M (encoded by ITGAM) is associated with systemic lupus erythematosus
We identified and replicated an association between ITGAM (CD11b) at 16p11.2 and risk of systemic lupus erythematosus (SLE) in 3,818 individuals of European descent. The strongest association was at a nonsynonymous SNP, rs1143679 (P = 1.7 × 10?17, odds ratio = 1.78). We further replicated this association in two independent samples of individuals of African descent (P = 0.0002 and 0.003; overall meta-analysis P = 6.9 × 10?22). The genetic association between ITGAM and SLE implicates the ?M?2-integrin adhesion pathway in disease development.
In a sharp turnaround, the Republican candidates has opened a 5-point lead on his Democratic rival and is seen as a stronger manager of the economy, according to a Reuters/Zogby poll.
AFP - Georgia's South Ossetia and Abkhazia regions planned rallies Thursday to ask Russia for recognition as independent states, two weeks after Russian troops occupied both provinces.
