A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk
To identify risk variants for colorectal cancer (CRC), we conducted a genome-wide association study, genotyping 550,163 tag SNPs in 940 individuals with familial colorectal tumor (627 CRC, 313 advanced adenomas) and 965 controls. We evaluated selected SNPs in three replication sample sets (7,473 cases, 5,984 controls) and identified three SNPs in SMAD7 (involved in TGF-? and Wnt signaling) associated with CRC. Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant (Ptrend = 1.0 × 10?12).
In a sharp turnaround, the Republican candidates has opened a 5-point lead on his Democratic rival and is seen as a stronger manager of the economy, according to a Reuters/Zogby poll.
AFP - Georgia's South Ossetia and Abkhazia regions planned rallies Thursday to ask Russia for recognition as independent states, two weeks after Russian troops occupied both provinces.
