A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15
F cells measure the presence of fetal hemoglobin, a heritable quantitative trait in adults that accounts for substantial phenotypic diversity of sickle cell disease and ? thalassemia. We applied a genome-wide association mapping strategy to individuals with contrasting extreme trait values and mapped a new F cell quantitative trait locus to BCL11A, which encodes a zinc-finger protein, on chromosome 2p15. The 2p15 BCL11A quantitative trait locus accounts for 15.1% of the trait variance.
The historic takeover of Fannie Mae and Freddie Mac, which could come as soon as this weekend, moved to the forefront of the presidential campaign Saturday.
In the arena that night, the whole last minute was drowned out by cheers — and then when the soaring music swelled, the confetti rained down as the harbinger of balloons and the hopeful first family took the stage, forget about it — it was a perfect end to a convention that last Monday, no one even knew if it would happen. But it did, and I'm so glad to have been there.
