Novel enzyme inhibitor paves way for new cancer drug
(The Wistar Institute) Wistar Institute scientists have developed a new type of enzyme inhibitor capable of blocking a biochemical pathway that plays a key role in cancer development. Based on studies in human melanoma cells, the research paves the way for developing new ways to treat cancer by dampening overactive enzyme activity that leads to uncontrolled tumor growth. The study shows how small-molecule inhibitors can be designed to target a family of signaling proteins, called phosphatidyl-inositol-3-kinases, or PI3Ks.
Democrat Barack Obama's appeal to  centrist voters has further opened the door to Republican claims his message of change only applies to the positions he has taken in the past.
AP - Iran indicated Saturday that it has no plans to meet a key Western demand that it stop enriching uranium, a day after Tehran sent the European Union a response to an international offer of incentives for halting enrichment.
AP - The call girl involved in a scandal that brought down New York's former governor has dropped a lawsuit claiming "Girls Gone Wild" founder Joe Francis exploited her image and name on the Internet.
